In contrast, circulating IgG molecules have a half-life of about 21 to 28 days. Circulating IgA has a half-life of about 3 days, and circulating IgM has a halflife of about 4 days. IgE has a very short half-life of about 2 days in the circulation (although cell-bound IgE associated with the high-affinity IgE receptor on mast cells has a very long half-life see Chapter 19). Different antibody isotypes have very different half-lives in circulation.
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